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Updated: Jun 24, 2026
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American Society of Microbiology ABMM Sample Questions:
1. A clinical microbiology laboratory is implementing a new laboratory information system (LIS). A critical step in the validation process is ensuring the accurate and reliable transfer of data, including patient demographics, test orders, and results. This aspect of validation primarily focuses on:
A) Workflow efficiency and user training.
B) Clinical sensitivity and specificity.
C) Data integrity and interoperability.
D) Analytical sensitivity and specificity.
2. Which of the following organisms is an obligate intracellular bacterium transmitted by arthropod vectors and is a common cause of Rocky Mountain Spotted Fever?
A) Coxiella burnetii
B) Chlamydia trachomatis
C) Borrelia burgdorferi
D) Rickettsia rickettsii
3. Microscopic examination of a trichrome-stained stool smear reveals amoebic trophozoites approximately 25
µm in diameter, containing ingested red blood cells. The nucleus, when visible, has fine, evenly distributed peripheral chromatin and a small, central karyosome. These features are diagnostic for:
A) Iodamoeba bütschlii
B) Entamoeba histolytica
C) Entamoeba coli
D) Endolimax nana
4. Which virus is recognized as the leading cause of sporadic, severe gastroenteritis in infants and young children globally, for which effective vaccines are now available?
A) Astrovirus
B) Enteric Adenovirus (serotypes 40, 41)
C) Rotavirus
D) Norovirus
5. Transmissible spongiform encephalopathies (TSEs), such as Creutzfeldt-Jakob disease (CJD) in humans and Bovine Spongiform Encephalopathy (BSE) in cattle, are caused by infectious agents composed primarily of:
A) Aberrantly folded host-encoded prion proteins (PrP<sup>Sc</sup>)
B) Defective viral particles requiring a helper virus
C) Slow-growing bacteria lacking a cell wall
D) Viroids (small, circular RNA molecules)
Solutions:
| Question # 1 Answer: C | Question # 2 Answer: D | Question # 3 Answer: B | Question # 4 Answer: C | Question # 5 Answer: A |
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